El plasma rico en plaquetas como una estrategia prometedora para el tratamiento del síndrome de Asherman
DOI:
https://doi.org/10.59169/pentaciencias.v5i6.863Palabras clave:
Plasma rico en plaquetas; Síndrome de Asherman; Adherencias intrauterinas; Recidiva de las adherencias; Patrón menstrualResumen
El síndrome de Asherman (SA) es causa importante de infertilidad y alteraciones del patrón menstrual. El objetivo de esta revisión fue evaluar la evidencia científica sobre la eficacia del plasma rico en plaquetas en mujeres en edad fértil con síndrome de Asherman para evitar la formación de nuevas adherencias, mejorar la fecundidad y disminuir los síntomas menstruales relacionados. Se recopilaron artículos científicos de bases de datos (PubMed, Google académico, Springer, Wiley online library, Taylor and Francis online, Scopus, Scielo), realizados en mujeres con síndrome de Asherman, sometidas a la infusión de plasma rico en plaquetas (PRP). Se seleccionaron 27 artículos, ocho de ellos están a favor de su uso, ya que demostraron mejoría en la función endometrial, a pesar de no encontrar hallazgos estadísticamente significativos. Mientras que, seis investigaciones recomiendan realizar nuevos ensayos. En conclusión, los estudios analizados en su mayoría recomiendan el empleo de plasma rico en plaquetas en el tratamiento del síndrome de Asherman, ya que disminuyó las recidivas, mejoró las tasas de embarazos y restableció del patrón menstrual. A pesar de que algunos de ellos no encontraron un beneficio evidente, por los mínimos efectos observados, este factor debe investigarse, ya que puede estar influido por variables adicionales.
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Aghajanova, L., Cedars, M. I., & Huddleston, H. G. (2018). Platelet-rich plasma in the management of asherman syndrome: Case report. Journal of Assisted Reproduction and Genetics, 35(5), 771–775. https://doi.org/10.1007/s10815-018-1135-3
Aghajanova, Lusine, Sundaram, V., Kao, C. N., Letourneau, J. M., Manvelyan, E., Cedars, M. I., & Huddleston, H. G. (2021). Autologous platelet-rich plasma treatment for moderate-severe Asherman syndrome: the first experience. Journal of Assisted Reproduction and Genetics, 38(11), 2955–2963. https://doi.org/https://doi.org/10.1007/s10815-021-02328-5
Ahmed, M., Mohamed, A., & Walaa, A. (2021). Plasma rico en plaquetas después de la adhesólisis histeroscópica.pdf. International Journal of Reproduction, Contraception, Obstetrics and Ginecology, 10(2), 433–438. https://doi.org/https://dx.doi.org/10.18203/2320-1770.ijrcog20210289
Albazee E, Al-Rshoud F, Almahmoud L, Al Omari B, Alnifise M, B. S. (2022). Platelet-rich plasma for the management of intrauterine adhesions: A systematic review and meta-analysis of randomized controlled trials. Journal of Gynecology Obstetrics and Human Reproduction, 51(2). https://doi.org/10.1016/j.jogoh.2021.102276
Berek, J. (2013). Berek y Novak Ginecología (T. Hengst (ed.); 15th ed.).
Boudová, B., Lisá, Z., Richtárová, A., Kužel, D., & Mára, M. (2021). Prevention of de novo adhesion formation in patients with asherman’s syndrome. Ceska Gynekologie, 86(4), 273–278. https://doi.org/10.48095/cccg2021273
Cao, Y., Zhu, X., Zhou, R., He, Y., Wu, Z., & Chen, Y. (2021). A narrative review of the research progress and clinical application of platelet-rich plasma. Annals of Palliative Medicine, 10(4), 4823–4829. https://doi.org/10.21037/apm-20-2223
de Miguel-Gómez, L., Romeu, M., Pellicer, A., & Cervelló, I. (2021). Strategies for managing Asherman’s syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach. Molecular Reproduction and Development, 88(8), 527–543. https://doi.org/10.1002/mrd.23523
Dreisler, E., & Kjer, J. J. (2019a). Asherman’s syndrome: Current perspectives on diagnosis and management. International Journal of Women’s Health, 11, 191–198. https://doi.org/10.2147/IJWH.S165474
Dreisler, E., & Kjer, J. J. (2019b). Asherman’s syndrome: Current perspectives on diagnosis and management. International Journal of Women’s Health, 11, 191–198. https://doi.org/10.2147/IJWH.S165474
Hajipour, H., Farzadi, L., Latifi, Z., Keyhanvar, N., Navali, N., Fattahi, A., Nouri, M., & Dittrich, R. (2021). An update on platelet-rich plasma (PRP) therapy in endometrium and ovary related infertilities: clinical and molecular aspects. Systems Biology in Reproductive Medicine, 67(3), 177–188. https://doi.org/10.1080/19396368.2020.1862357
Hoffman, B., Schorge, J., Schaffer, J., Halvorson, L., Bradshaw, K., & Cunningham, G. (2014). WILLIAMS GINECOLOGIA (N. L. G. Carbajal (ed.); 2nd ed.).
Javaheri, A., Kianfar, K., Pourmasumi, S., & Eftekhar, M. (2020). Platelet-rich plasma in the management of Asherman’s syndrome: An RCT. International Journal of Reproductive BioMedicine, 18(2), 113–120. https://doi.org/10.18502/ijrm.v18i2.6423
Korany S, Baradwan S, Badghish E, Talat Miski N, Alshahrani MS, Khadawardi K, et al. (2022). Value of intrauterine platelet-rich concentrates in patients with intrauterine adhesions after hysteroscopy: A systematic review and meta- analysis of randomized controlled trials. European Journal of Obstetrics and Gynecology and Reproductive Biology, 271, 63–70. https://doi.org/10.1016/j.ejogrb.2022.01.030
Kusumi, M., Ihana, T., Kurosawa, T., Ohashi, Y., & Tsutsumi, O. (2020). Intrauterine administration of platelet-rich plasma improves embryo implantation by increasing the endometrial thickness in women with repeated implantation failure: A single-arm self-controlled trial. Reproductive Medicine and Biology, 19(4), 350–356. https://doi.org/10.1002/rmb2.12334
Manchanda, R. (2021). Intra Uterine Adhesions. In R. Manchanda (Ed.), Intra Uterine Adhesions. https://doi.org/10.1007/978-981-33-4145-6
Manchanda, R., Rathore, A., Carugno, J., Della Corte, L., Tesarik, J., Török, P., Vilos, G. A., & Vitale, S. G. (2021). Classification systems of Asherman’s syndrome. An old problem with new directions. Minimally Invasive Therapy and Allied Technologies, 30(5), 304–310. https://doi.org/10.1080/13645706.2021.1893190
Mouanness, M., Ali-Bynom, S., Jackman, J., Seckin, S., & Merhi, Z. (2021). Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for Endometrial Receptivity and Thickness: a Literature Review of the Mechanisms of Action. Reproductive Sciences, 28(6), 1659–1670. https://doi.org/10.1007/s43032-021-00579-2
Naghshineh, E., Rouholamin, S., & Derakhshandeh, Z. (2023). Hormone Therapy with or without Platelet ‑ Rich Plasma ( PRP ) for Treatment Asherman Syndrome ; A Randomized Clinical Trial. Advanced Biomedical Research, 13, 1–5. https://doi.org/10.4103/abr.abr_411_21
Peng, J., Li, M., Zeng, H., Zeng, Z., Huang, J., & Liang, X. (2020). Intrauterine infusion of platelet-rich plasma is a treatment method for patients with intrauterine adhesions after hysteroscopy. International Journal of Gynecology and Obstetrics, 151(3), 362–365. https://doi.org/10.1002/ijgo.13353
Puente Gonzalo, E., Alonso Pacheco, L., Vega Jiménez, A., Vitale, S. G., Raffone, A., & Laganà, A. S. (2021). Intrauterine infusion of platelet-rich plasma for severe Asherman syndrome: a cutting-edge approach. Updates in Surgery, 73(6), 2355–2362. https://doi.org/10.1007/s13304-020-00828-0
Qiu, D., Xiao, X., Wang, W., Zhang, W., & Wang, X. (2023). Platelet-Rich Plasma Improves Pregnancy Outcomes in Moderate to Severe Intrauterine Adhesion: A Retrospective Cohort Study. Journal of Clinical Medicine, 12(4), 1–9. https://doi.org/10.3390/jcm12041319
Sameh, A., Abdellatif, M., IBRAHIM, M., & Ghanem, R. (2020). Intrauterine Use of Autologous Platelet-Rich Plasma in Management of Asherman Syndrome: A Randomized Controlled Trial. Evidence Based Women’s Health Journal, 11(1), 56–67. https://doi.org/10.21608/ebwhj.2020.27971.1087
Sevinç, F., Oskovi-Kaplan, Z. A., Çelen, Ş., Ozturk Atan, D., & Topçu, H. O. (2021). Identifying the risk factors and incidence of Asherman Syndrome in women with post-abortion uterine curettage. Journal of Obstetrics and Gynaecology Research, 47(4), 1549–1555. https://doi.org/10.1111/jog.14667
Sharara, F. I., Lelea, L. L., Rahman, S., Klebanoff, J. S., & Moawad, G. N. (2021). A narrative review of platelet-rich plasma (PRP) in reproductive medicine. Journal of Assisted Reproduction and Genetics, 38(5), 1003–1012. https://doi.org/10.1007/s10815-021-02146-9
Shen, M., Duan, H., Lv, R., & Lv, C. (2022). Efficacy of autologous platelet-rich plasma in preventing adhesion reformation following hysteroscopic adhesiolysis: a randomized controlled trial. Reproductive BioMedicine Online, 45(6), 1189–1196. https://doi.org/10.1016/j.rbmo.2022.07.003
Shi, X., Saravelos, S. H., Zhou, Q., Huang, X., Xia, E., & Li, T. C. (2019). Prevention of postoperative adhesion reformation by intermittent intrauterine balloon therapy: a randomised controlled trial. BJOG: An International Journal of Obstetrics and Gynaecology, 126(10), 1259–1266. https://doi.org/10.1111/1471-0528.15843
Tang, R., Xiao, X., He, Y., Qiu, D., Zhang, W., & Wang, X. (2023). Clinical evaluation of autologous platelet-rich plasma therapy for intrauterine adhesions : a systematic review and. Frontiers in Endocrinology, 14, 1–11. https://doi.org/10.3389/fendo.2023.1183209
Varghese, J., & Acharya, N. (2022). Platelet-Rich Plasma: A Promising Regenerative Therapy in Gynecological Disorders. Cureus, 14(9), 1–5. https://doi.org/10.7759/cureus.28998
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