Resistencia antimicrobiana en el contexto actual

Harry Arturo  García Balda; Mauricio  Palacios

Authors

Harry Arturo García Balda
Mauricio Palacios

Keywords:

Drug Resistance; Microbe; antibacterial agents.

Abstract

The current resistance of germs to antimicrobials constitutes a major health problem throughout the world. Bacterial resistance mechanisms can be intrinsic or adaptive. A bibliographic search was carried out in different databases: Clinical Evidence, The Cochrane Library, PUBMED, MEDLINE, LIS, Scielo, Medscape, LILIACS, Latindex, HINARI, MEDIGRAPHIC – NEWS, NIH Repórter, Google Scholar and on the PAHO website. /WHO on the issues of bacterial resistance and its mechanisms. It was found that there are several genes that promote bacterial resistance, which have mutated, acquiring greater resistance to a large number of antibiotics, including intrahospital antibiotics, such as carbapenems and third and fourth generation cephalosporins. These same genes can be transmitted between different microorganisms through 4 different mechanisms: transformation, transduction, transposition and conjugation. Knowledge of the mechanisms of bacterial resistance will allow better antimicrobial therapy and help in the design of new drugs. Resistance is not only intrinsic, but also adaptive, which we must take into account to establish appropriate treatment regimens.

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