Performance in Adolescents from Milagro, Ecuador Applications of Personalized Nutrition Based on Gut Microbiota Profiling for the Prevention of Metabolic Diseases: A Systematic Review
DOI:
https://doi.org/10.59169/pentaciencias.v7i5.1676Keywords:
personalized nutrition; gut microbiota; metabolic diseases; PRISMA 2020; PICO; systematic review.Abstract
This research is based on a systematic review that analyzed twelve studies published between 2022 and 2024 on the application of personalized nutrition based on the gut microbiota profile in the prevention of metabolic diseases. The PRISMA 2020 guidelines and the PICO framework were applied to define population, intervention, comparator, and outcomes. Most included studies were randomized clinical trials and systematic reviews assessing individualized diets, probiotics, prebiotics, and resistant starch in relation to gut microbiota composition and metabolic parameters. The findings show consistent improvements in microbial diversity, glucose regulation, lipid profile, inflammation, and blood pressure. Personalized nutrition guided by microbiome profiling emerges as an effective and adaptable strategy to prevent metabolic disorders, although further methodological standardization and cross-population validation remain necessary.
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Andersen, C. J., & Fernandez, M. L. (2024). Emerging Biomarkers and Determinants of Lipoprotein Profiles to Predict CVD Risk: Implications for Precision Nutrition. Nutrients, 17(1), 42. https://doi.org/10.3390/nu17010042
Ayakdaş, G., & Ağagündüz, D. (2023). Microbiota-accessible carbohydrates (MACs) as novel gut microbiome modulators in noncommunicable diseases. Heliyon, 9(9), e19888. https://doi.org/10.1016/j.heliyon.2023.e19888
Bermingham, K. M., Linenberg, I., Polidori, L., Asnicar, F., Arrè, A., Wolf, J., Badri, F., Bernard, H., Capdevila, J., Bulsiewicz, W. J., Gardner, C. D., Ordovas, J. M., Davies, R., Hadjigeorgiou, G., Hall, W. L., Delahanty, L. M., Valdes, A. M., Segata, N., Spector, T. D., & Berry, S. E. (2024). Effects of a personalized nutrition program on cardiometabolic health: A randomized controlled trial. Nature Medicine, 30(7), 1888-1897. https://doi.org/10.1038/s41591-024-02951-6
Cagliari, E. B., Craveiro, I., Santos, F. R. A., & Rehem, T. C. (2024). Meta-evaluation as a controlled descriptor: A fundamental step to qualify searches and expand studies in the health area. Physis: Revista de Saúde Coletiva, 34, e34085.
Carra, M. C., Romandini, P., & Romandini, M. (2025). Risk of Bias Evaluation of Cross‐Sectional Studies: Adaptation of the Newcastle‐Ottawa Scale. Journal of Periodontal Research, jre.13405. https://doi.org/10.1111/jre.13405
Chen, Z., Liang, N., Zhang, H., Li, H., Guo, J., Zhang, Y., Chen, Y., Wang, Y., & Shi, N. (2024). Resistant starch and the gut microbiome: Exploring beneficial interactions and dietary impacts. Food Chemistry: X, 21, 101118. https://doi.org/10.1016/j.fochx.2024.101118
Cumpston, M. S., McKenzie, J. E., Thomas, J., & Brennan, S. E. (2021). The use of ‘PICO for synthesis’ and methods for synthesis without meta-analysis: Protocol for a survey of current practice in systematic reviews of health interventions. F1000Research, 9, 678.
de Cuevillas, B., Riezu-Boj, J. I., Abete, I., Zulet, M. A., Galarregui, C., Gonzalez-Navarro, C. J., Milagro, F. I., Martínez, J. A., & Navas-Carretero, S. (2022). Possible metabolic interplay between quality of life and fecal microbiota in a presenior population: Preliminary results. Nutrition, 103-104, 111841. https://doi.org/10.1016/j.nut.2022.111841
Guilherme Guedert, D., De Lima, P., Souza E Silva, R., & Cláudia Carneiro Girão Carmona, V. (2022). The use of active methodologies for the teaching of human embryology: A systematic review. Anatomia, Histologia, Embryologia, 51(3), 332-338. https://doi.org/10.1111/ahe.12803
Guizar-Heredia, R., Noriega, L. G., Rivera, A. L., Resendis-Antonio, O., Guevara-Cruz, M., Torres, N., & Tovar, A. R. (2023). A new approach to personalized nutrition: Postprandial glycemic response and its relationship to gut microbiota. Archives of Medical Research, 54(3), 176-188.
Iacomino, G., Rufián Henares, J. Á., & Lauria, F. (2024). Editorial: Personalized nutrition and gut microbiota: current and future directions. Frontiers in Nutrition, 11. https://doi.org/10.3389/fnut.2024.1375157
Kallapura, G., Prakash, A. S., Sankaran, K., Manjappa, P., Chaudhary, P., Ambhore, S., & Dhar, D. (2024). Microbiota based personalized nutrition improves hyperglycaemia and hypertension parameters and reduces inflammation: A prospective, open label, controlled, randomized, comparative, proof of concept study. PeerJ, 12, e17583. https://doi.org/10.7717/peerj.17583
Larik, G. N. F., Canfora, E. E., van Schothorst, E. M., & Blaak, E. E. (2024). Intestinal gases as a non-invasive measurement of microbial fermentation and host health. Cell Host & Microbe, 32(8), 1225-1229. https://doi.org/10.1016/j.chom.2024.07.004
Larrosa, M., Martínez-López, S., González-Rodríguez, L. G., Loria-Kohen, V., & de Lucas, B. (2022). [Microbiota-diet interactions: Towards personalized nutrition]. Nutricion Hospitalaria, 39(Spec No3), 39-43. https://doi.org/10.20960/nh.04309
Li, C. (2023). Understanding interactions among diet, host and gut microbiota for personalized nutrition. Life Sciences, 312, 121265.
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., & Brennan, S. E. (2022). The PRISMA 2020 statement: An updated guideline for reporting systematic reviewsDeclaracion PRISMA 2020: una guia actualizada para la publicacion de revisiones sistematicas. Revista panamericana de salud publica= Pan American journal of public health, 46, e112-e112.
Palmnäs-Bédard, M. S. A., Costabile, G., Vetrani, C., Åberg, S., Hjalmarsson, Y., Dicksved, J., Riccardi, G., & Landberg, R. (2022). The human gut microbiota and glucose metabolism: A scoping review of key bacteria and the potential role of SCFAs. The American Journal of Clinical Nutrition, 116(4), 862-874. https://doi.org/10.1093/ajcn/nqac217
Ramos-Lopez, O. (2022). Multi-Omics Nutritional Approaches Targeting Metabolic-Associated Fatty Liver Disease. Genes, 13(11), 2142. https://doi.org/10.3390/genes13112142
Schiavenato, M., & Chu, F. (2021). PICO: What it is and what it is not. Nurse education in practice, 56, 103194.
Simon, M.-C., Sina, C., Ferrario, P. G., Daniel, H., & Society, W. G. “Personalized N. of the G. N. (2023). Gut Microbiome Analysis for Personalized Nutrition: The State of Science. Molecular Nutrition & Food Research, 67(1), 2200476. https://doi.org/10.1002/mnfr.202200476
van de Put, M., van den Belt, M., de Wit, N., & Kort, R. (2024). Rationale and design of a randomized placebo-controlled nutritional trial embracing a citizen science approach. Nutrition Research, 131, 96-110. https://doi.org/10.1016/j.nutres.2024.07.008
Wang, A., Guan, B., Zhang, H., & Xu, H. (2023). Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases. Pharmacological Research, 198, 106983. https://doi.org/10.1016/j.phrs.2023.106983
Yang, Z., Yang, M., Deehan, E. C., Cai, C., Madsen, K. L., Wine, E., Li, G., Li, J., Liu, J., & Zhang, Z. (2024). Dietary fiber for the prevention of childhood obesity: A focus on the involvement of the gut microbiota. Gut Microbes, 16(1), 2387796. https://doi.org/10.1080/19490976.2024.2387796
Zhang, P. (2022). Influence of foods and nutrition on the gut microbiome and implications for intestinal health. International journal of molecular sciences, 23(17), 9588.
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