Índices aterogénicos como predictores del síndrome metabólico. Una revisión bibliográfica

Holger Gustavo  García Gaibor; Edison Arturo  Galárraga Pérez

Authors

Holger Gustavo García Gaibor
Edison Arturo Galárraga Pérez

Keywords:

Metabolic syndrome; atherogenic index; cardiovascular disease; diabetes mellitus, type II; atherosclerosis; cholesterol.

Abstract

The metabolic syndrome leads to cardiovascular diseases and type II diabetes mellitus. For its laboratory diagnosis, atherogenic indices have been proposed that allow a more detailed lipid profile. To describe the main atherogenic indices that allow prediction of metabolic syndrome. A comprehensive search and review was conducted in Medline, Pubmed, SciELO, EMBASE, Lilacs, Cochrane Library and Web of Science databases. The 29 articles of greatest relevance and novelty were selected. Atherogenic indices constitute the quantitative expression of the link between clinical and metabolic expressions of lipid fractions. Ten indices have been described so far and any of them is effective in diagnosing the risk of atherosclerosis; the most used is that of Castelli I. Certain risk factors influence its predictive value. The atherogenic indices allow prediction of diabetes and cardiovascular diseases and their possible complications once the disease is established, they also help reduce the use of expensive and invasive diagnostic means and guide therapeutic management. The atherogenic index of plasma has increased its use, especially in the diagnosis of metabolic syndrome and as a guide for treatment. Atherogenic indices are surrogate markers for predicting the risk of cardiovascular disease and diabetes; Their use should be expanded to reinforce and/or replace diagnostic means and serve as indicators of therapeutic procedures. It is requested to insert its use and monitoring in routine clinical practice.

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References

Carvajal Carvajal, C. (2017). Síndrome metabólico: definiciones, epidemiología, etiología, componentes y tratamiento. Med. leg. Costa Rica., 34(1), 175-193. http://www.scielo.sa.cr/scielo.php?script=sci_arttext&pid=S1409-00152017000100175&lng=es

De la Torre-Cisneros, K., Acosta-Rodríguez, Z., & Aragundi-Intriago, V. (2019). Utilidad clínica de los índices aterogénicos para valoración de riesgo cardiovascular: un enfoque desde el laboratorio clínico. Dominio de las Ciencias, 5, 57.

Dessie, G. (2022). Association of atherogenic indices with C-reactive protein and risk factors to assess cardiovascular risk in rheumatoid arthritis patient at Tikur Anbessa Specialized Hospital, Addis Ababa. PLoS One, 17(6), e0269431. 0 (Cholesterol, HDL)

Figueroa-Balladares, J. E., Arguello-Tumbaco, J. J., & Azua-Menéndez, M. (2021). Importancia del perfil lipídico e índices aterogénicos en el seguimiento del riesgo cardiovascular en mujeres menopáusicas. Dom. Cien., 7(2), 151-167.

Guo, J., Wang, A., Wang, Y., Liu, X., Zhang, X., Wu, S., & Zhao, X. (2021). Non-traditional lipid parameters as potential predictors of asymptomatic intracranial arterial stenosis. Front Neurol. , 12, 679415.

Gupta, M., Tummala, R., Ghosh, R. K., Blumenthal, C., Philip, K., Bandyopadhyay, D., Ventura, H., & Deedwania, P. (2019). An update on pharmacotherapies in diabetic dyslipidemia. Prog Cardiovasc Dis., 62(4), 334-341. 0 (Anticholesteremic Agents)

Heeren, J., & Scheja, L. (2021). Metabolic-associated fatty liver disease and lipoprotein metabolism. Mol Metab., 50, 101238. 0 (Fatty Acids)

Ismaiel, A., Ciobanu, O. S., Ismaiel, M., Leucuta, D., Popa, S., David, L., Ensar, D., Al Srouji, N., & Dumitrascu, D. L. (2022). Atherogenic index of plasma in non-alcoholic fatty liver disease: systematic review and meta-analysis. . Biomedicines., 10(9), 2101.

Kim, J. J., Yoon, J. A.-O., Lee, Y. A.-O. X., Park, B. A.-O., & Jung, D. A.-O. (2021). Predictive value of the atherogenic index of plasma (AIP) for the risk of incident ischemic heart disease among non-diabetic koreans. . Nutrients, 13(9), 3231. 0 (Lipids)

Leister, K. R., Cilhoroz, B. T., Rosenberg, J., Brown, E. C., & Kim, J. Y. (2022). Metabolic syndrome: operational definitions and aerobic and resistance training benefits on physical and metabolic health in children and adolescents. Diabetes Metab Syndr, 16(6), 102530.

Li, Y. W., Kao, T. W., Chang, P. K., Chen, W. L., & Wu, L. W. (2021). Atherogenic index of plasma as predictors for metabolic syndrome, hypertension and diabetes mellitus in Taiwan citizens: a 9-year longitudinal study. Sci Rep., 10(11), 9900. 0 (Cholesterol, HDL)

Liu, T. A.-O., Liu, J., Wu, Z., Lv, Y., & Li, W. A.-O. (2021). Predictive value of the atherogenic index of plasma for chronic total occlusion before coronary angiography. Clin Cardiol., 44(4), 518-525. 0 (Cholesterol, HDL)

López González, Á. A., Rivero Ledo, Y. I., Vicente Herrero, M. T., Gil Llinás, M., Tomás Salvá, M., & Riutord Fe, B. (2015). Índices aterogénicos en trabajadores de diferentes sectores laborales del área mediterránea española. Clínica e Investigación en Arteriosclerosis, 27(3), 118-128.

Mahat, R. K., Singh, N., Rathore, V., Gupta, A., & Shah, R. K. (2018). Relationship between atherogenic indices and carotid intima-media thickness in prediabetes: a cross-sectional study from Central India. . Med Sci (Basel), 6(3), 55.

Mahmoodi, M., & Najafipour, H. (2022). Associations between serum vitamin D(3), atherogenic indices of plasma and cardiometabolic biomarkers among patients with diabetes in the KERCADR study. BMC Endocr Disord., 22(1), 126. 0 (Biomarkers)

Mayoral-Andrade G, Pérez-Campos E, Majluf-Cruz A, PérezCampos Mayoral L, & G., V.-M. (2021). Modulación de los índices de resistencia a la insulina e índice aterogénico del plasma posterior al tratamiento con ácidos grasos omega 3. Avan C Salud Med., 8(1), 3-7. https://www.oaxaca.gob.mx/salud/wp-content/uploads/sites/32/2021/11/Articulo-Original-1_Modulacion-de-los-indices-de-resistencia-a-la-insulinamodulacion.pdf

Moussavi Javardi, M. S., Madani, Z., Movahedi, A. A.-O. X., Karandish, M., & Abbasi, B. (2020). The correlation between dietary fat quality indices and lipid profile with atherogenic index of plasma in obese and non-obese volunteers: a cross-sectional descriptive-analytic case-control study. Lipids Health Dis., 19(1), 213. 0 (Dietary Fats)

Paramio Rodríguez, A., Sarría, Y., & Gálvez, R. (2022). Síndrome metabólico en personas mayores de 40 años del primer nivel de atención. . Rev Finlay., 12(1), 8 pag. http://www.revfinlay.sld.cu/index.php/finlay/article/view/1061

Pedro-Botet, J., Ascaso, J. F., Blasco, M., Brea, Á., Díaz, Á., Hernández-Mijares, A., Pintó, X., & Millán, J. (2020). Triglicéridos, colesterol HDL y dislipidemia aterogénica en la guía europea para el control de las dislipidemias 2019. Clin Invest Arterioscl., 32(5), 209-218.

Pérez-Martín AR, Castro-Eguiluz D, Cetina-Pérez L, V.-T. Y., Bahena-González A, Montes-Servín E, González-Ibarra E, Espinosa-Romero R, & Gallardo-Rincón, D. (2022). Impact of metabolic syndrome on the risk of endometrial cancer and the role of lifestyle in prevention. Bosn J Basic Med Sci., 22(4), 499-510.

Qin, Z., Zhou, K., Li, Y., Cheng, W., Wang, Z., Wang, J., Gao, F., Yang, L., Xu, Y., Wu, Y., He, H., & Zhou, Y. A.-O. (2020). The atherogenic index of plasma plays an important role in predicting the prognosis of type 2 diabetic subjects undergoing percutaneous coronary intervention: results from an observational cohort study in China. Cardiovasc Diabetol., 19(1), 23. https://doi.org/https://doi.org/10.1186/s12933-020-0989-8. 0 (Biomarkers)

Qujeq, D., Mahrooz, A. A.-O., Alizadeh, A., Masoumi, P., Annemohammadzadeh, S., & Boorank, R. (2018). Genotype and phenotype of salt-stimulated paraoxonase 1 (PON1) is associated with atherogenic indices in type 2 diabetes. J Diabetes Metab Disord., 17(1), 1-10.

Rhee, E.-J. (2022). The influence of obesity and metabolic health on vascular health. Endocrinol Metab (Seoul), 37(1), 1-8.

Shen, S. W., Lu, Y., Li, F., Yang, C. J., Feng, Y. B., Li, H. W., Yao, W. F., & Shen, Z. H. (2018). Atherogenic index of plasma is an effective index for estimating abdominal obesity. Lipids Health Dis., 17(1), 11.

Silveira Rossi JL, Barbalho SM, Reverete de Araujo R, Bechara MD, Sloan KP, & LA., S. (2022). Metabolic syndrome and cardiovascular diseases: Going beyond traditional risk factors. . Diabetes Metab Res Rev., 38(3), e3502.

Turgay Yıldırım, Ö., & Kaya, Ş. (2021). The atherogenic index of plasma as a predictor of mortality in patients with COVID-19. Heart Lung., 50(2), 329-333. 0 (Triglycerides)

Wang, Q., Zheng, D., Liu, J., Fang, L., & Li, Q. (2018). Atherogenic index of plasma is a novel predictor of non-alcoholic fatty liver disease in obese participants: a cross-sectional study. Lipids Health Dis., 17(1), 284. EC 2.3.2.2 (gamma-Glutamyltransferase)

Wu, J., Zhou, Q., Wei, Z., Wei, J., & Cui, M. (2021). Atherogenic Index of Plasma and Coronary Artery Disease in the Adult Population: A Meta-Analysis., 8, 817441.

Yuvaraj, J., Isa, M., Che, Z. C., Lim, E., Nerlekar, N., Nicholls, S. J., Seneviratne, S., Lin, A., Dey, D., & Wong, D. T. L. (2022). Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography. Sci Rep., 12, 9626.